Pacijente treba pažljivo pratiti u cilju prepoznavanja znakova i simptoma respiratorne depresije i sedacije. U ovom pogledu se preporučuje informisanje pacijenata i njihovih staratelja (kada je to primenljivo) o značajnosti prepoznavanja ovih simptoma (videti odeljak 4.five).
S obzirom na to da je rizik od pojave fenomena obustave/rebound fenomena veći ukoliko se terapija naglo prekine, preporučuje se postepeno smanjivanje doze.
Itrakonazol, ketokonazol i u manjoj meri flukonazol i vorikonazol su snažni inhibitori izoenzima CYP3A4 citohroma P450 i mogu povećati koncentraciju benzodiazepina u plazmi.
Abruptly halting this medication may perhaps result in withdrawal, particularly when you've employed it for a long time or in substantial doses. To forestall withdrawal, your health practitioner could reduced your dose little by little.
FDA Drug Safety Conversation: FDA restricts use of prescription codeine ache and cough medicines and tramadol discomfort medicines in small children; recommends from use in breastfeeding Ladies
Usled naglog prekida terapije benzodiazepinima kod pacijenata sa epilepsijom i drugih pacijenata koji u anamnezi imaju epileptične napade može doći do pojave konvulzija ili epileptičnog statusa.
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Zbog toga u početnim fazama lečenja doze treba prilagoditi uz poseban oprez. Neželjena dejstva mogu biti izraženija prilikom upotrebe hidantoina ili barbiturata.
Podeona linija služi samo da olakša lomljenje da bi se lek lakše progutao, a ne za podelu na jednake doze.
Dejstvo benzodiazepina može biti pojačano i produženo prilikom istovremene upotrebe. Može biti potrebno smanjenje doze benzodiazepina.
Codeine is transformed into a powerful opioid drug (morphine) in One's body. In some individuals, this transformation happens faster plus much more fully than common, which raises the risk of pretty critical Negative effects.
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This is simply not an entire listing of probable Unwanted effects. For those who notice other results not detailed earlier mentioned, Make contact with your medical doctor or pharmacist.
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